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Table 1 First symptoms of the disease in late-infantile and juvenile MLD

From: Language and cognition in children with metachromatic leukodystrophy: onset and natural course in a nationwide cohort

First symptoms

Late-infantile (n = 23)

Juvenile (n = 36)

p

 

n

%

n

%

 

Gait disturbance

16

70%

25

69%

0.9922

Pain

6

26%

5

14%

0.2447

Abnormal movement patterns

14

61%

25

69%

0.5011

Impaired fine motor skills

4

17%

22

61%

0.0011

Restlessness/irritability

4

17%

10

28%

0.3645

Weakness

10

43%

13

36%

0.5748

Problems in concentration

0

0%

23

64%

0.0001

Behavioural problems

3

13%

20

56%

0.0012

Developmental regression in general

14

61%

19

53%

0.5449