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Table 5 List of other syndromes where hamartomatous polyps are frequent

From: Hamartomatous polyposis syndromes: A review

  Clinical hallmarks Gene Cancer
Gorlin syndrome Keratocysts of the jaw, hyperkeratosis of palm and soles, basal cell carcinomas, skeleton abnormalities, macrocephaly, frontal bossing PTCH1 Basal cell carcinomas, medullablastoma
Multiple endocrine neoplasia type 2B Mucosal neuromas of the lips an tongue, medullated corneal nerve fibers, distinctive facies with enlarged lips and tongue, an asthenic “marfarnoid habitus, and medullary thyroid cancer. RET Medullary thyroid cancer, pheochromocytoma
Neurofibromatosis type 1 Café au lait spots, axillary and inguinal freckling, and neurofibromas. NF1 Optic gliomas, malignant peripherical nerve sheath tumours, breast
Birt-Hogg-Dubé Skin fibrofolliculomas, spontaneous pneumothorax FLCN Renal