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Breast awareness starting at age 18 y
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Clinical breast exam, every 6–12 month, starting at age 25 y or 5–10 y before the earliest known breast cancer in the family
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Annual mammography and breast MRI screening starting at age 30–35 y or individualized based on earliest age of onset in family
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For endometrial cancer screening, encourage patient education and prompt response to symptoms and participation in a clinical trial to determine the effectiveness or necessity of screening modalities
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Discuss risk-reducing mastectomy and hysterectomy and counsel regarding degree of protection, extent of cancer risk and reconstruction options
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Address psychosocial, social, and quality-of-life aspects of undergoing risk-reducing mastectomy and/or hysterectomy
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Men and Woman
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Annual comprehensive physical exam starting at age 18 y or 5 y before the youngest age of diagnosis of a component cancer in the family (whichever comes first), with particular attention to breast and thyroid exam
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Annual thyroid starting at age 18 y or 5-10 y before the earliest known thyroid cancer in the family, whichever is earlier
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Colonoscopy, starting at age 35 y, then every 5 y or more frequently if patient is symptomatic or polyps found
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Consider renal ultrasound starting at age 40 y, then every 1-2 y
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Dermatological management may be indicated for some patients
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Consider psychomotor assessment in children at diagnosis and brain MRI if there are symptoms
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Education regarding the signs and symptoms of cancer
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