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Table 2 Updated risk level of drugs and toxins known to be associated with PAH

From: Pulmonary arterial hypertension

1. Definite

 
 

Aminorex

 

Fenfluramine

 

Dexfenfluramine

 

Toxic rapeseed oil

 

Benfluorex

2. Likely

 
 

Amphetamines

 

L-tryptophan

 

Metamphetamines

 

Dasatinib

3. Possible

 
 

Cocaine

Phenylpropanolamine

St John’s Wort

 

Chemotherapeutic agents

 

Selective serotonin reuptake inhibitors

 

Pergolide

4. Unlikely

 
 

Oral contraceptives

 

Estrogen therapy

 

Cigarette smoking

  1. *This table was adapted from Galiè et al. [15].
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172