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Table 1 Metabolites responsible for the differentiation between EBA mice and control mice

From: Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice

Random forest1

PLS-DA

Study A

Study B

Study A

Study B

ppm

Metabolites

ppm

Metabolites

ppm

Metabolites

ppm

Metabolites

0.97

leucine ↑2

1.07

n.a. ↑

8.35

n.a. ↑

8.43

n.a. ↑

3.17

histidine *↑

3.03

n.a. ↓

7.63

n.a. ↓

8.21

n.a.* ↑

1.01

isoleucine ↑

2.39

n.a. ↑

7.61

n.a. ↓

7.99

n.a.* ↑

1.05

valine ↑

1.21

n.a. ↑

7.51

n.a. ↓

7.91

n.a.* ↑

0.95

leucine, isoleucine ↑

3.07

n.a., tyrosine ↓

7.49

n.a. ↓

7.89

n.a.* ↑

2.33

n.a.3 ↓

0.91

n.a. ↑

7.45

phenylalanine ↑

7.75

tryptophane ↑

1.75

lysine, n.a. ↑

2.15

methionine, n.a. ↓

6.93

n.a., tyrosine ↑

7.73

tryptophane ↑

2.89

n.a.*

1.73

lysine ↓

6.91

tyrosine ↑

7.69

n.a. ↑

1.21

n.a. ↓

1.55

n.a. ↓

3.17

histidine* ↑

7.65

n.a. ↑

1.55

n.a. ↓

1.69

leucine ↓

2.89

n.a.* ↑

7.57

tryptophane, n.a. ↑

3.05

n.a, lysine. ↑

2.41

succinate ↑

1.57

n.a. ↓

7.55

tryptophane ↑

1.57

n.a. ↓

1.19

n.a. ↑

1.05

valine ↑

3.07

n.a. ↓

3.11

n.a. ↓

2.47

glutamine ↓

1.03

isoleucine, valine ↑

3.05

lysine, n.a. ↓

7.21

tyrosine ↑

3.05

n.a., lysine ↓

1.01

isoleucine ↑

3.03

n.a. ↓

2.41

succinate ↓

1.53

n.a. ↓

0.97

leucine ↑

1.21

n.a. ↑

1.03

isoleucine, valine ↑

3.01

n.a. ↓

0.95

leucine, isoleucine ↑

  

2.27

valine ↑

2.65

methionine, n.a. ↓

0.81

n.a. ↑

  

2.09

proline, n.a. ↓

7.33

phenylalanine ↑

    

3.15

*

1.43

n.a., isoleucine ↓

    

1.71

lysine, leucine ↑

1.47

alanine ↓

    

3.19

n.a., histidine ↓

1.85

lysine, n.a. ↓

    

1.93

acetate ↓

1.87

lysine ↓

    

1.97

n.a.; arginine ↑

0.93

isoleucine ↑

    

1.85

lysine, n.a. ↑

1.95

n.a.; arginine ↓

    

2.51

n.a. ↓

1.51

n.a. ↓

    

3.03

n.a.; lysine ↓

1.97

n.a.; arginine ↓

    

1.59

n.a. ↓

2.43

glutamine, n.a. ↑

    

7.19

tyrosine ↑

1.89

lysine ↓

    

7.35

phenylalanine ↑

1.71

lysine, leucine ↓

    

2.03

proline ↓

2.09

proline, n.a. ↓

    
  1. The ppm values of the buckets that are important in discriminating EBA and control mice are given with the metabolites that have been identified within these buckets. Buckets found in the random forest are listed according to the mean decrease of accuracy (see also Additional file1: Figure S4).
  2. 1 buckets are in sequence according to their contribution to the discrimination of EBA mice and control mice.
  3. 2 arrows show increase or decrease of metabolite levels in EBA.
  4. 3 n.a. signals could not be assigned.
  5. *strongly shifting peaks.