Table 2 Demographic features, ROTEM and CAT results of both groups
Characteristics | BD patients (N = 23) | Controls (N = 33) | p-value | |
|---|---|---|---|---|
Age at inclusion (year) | 49 ± 15 | 43 ± 10 | 0.082 | |
Female gender (%) | 78 | 63 | 0.241 | |
INTEM-α (degree) | 77 ± 3 | 74 ± 2 | <0.010 | |
ROTEM | INTEM-CFT (sec) | 66 ± 15 | 80 ± 14 | <0.010 |
INTEM-MCF (mm) | 61 ± 4 | 57 ± 4 | <0.010 | |
Platelet contribution-MCF (%) | 78 (69–79) | 79 (77–81) | 0.090 | |
Lag-time (min) | 6.7 ± 1.8 | 5.6 ± 1.1 | 0.025 | |
CAT | Time-to-peak (min) | 9.6 ± 1.9 | 9.0 ± 1.4 | 0.240 |
Peak height (nM) | 292 ± 65 | 213 ± 67 | <0.010 | |
ETP (nM × min) | 1543 ± 331 | 1286 ± 292 | 0.010 | |
Velocity index (nM/min) | 102 (83–127) | 55 (42–90) | <0.010 | |
Platelet count (×103/μl) | 217 (189–287) | 227 (199–247) | 0.785 | |
Erythrocyte count (×106/μl) | 4.2 ± 0.4 | 4.3 ± 0.4 | 0.244 | |
Fibrinogen (mg/l) | 321 ± 53 | 280 ± 42 | <0.010 | |
TAT (ng/l) | 19 (17–21) | 15 (12–17) | <0.010 | |
Other parameters | D-dimer (μg/l) | 293 ± 65 | 270 ± 86 | 0.480 |
tPA (antigen) (ng/ml) | 17.2 ± 7.2 | 12.4 ± 5.2 | 0.120 | |
PAI-1 (antigen) (ng/ml) | 19.9 ± 8.6 | 12.6 ± 6.0 | 0.032 | |
E-selectin (μg/l) | 24.2 ± 9.3 | 16.8 ± 8.4 | 0.040 | |
C-reactive protein (mg/dl) | 0.2 (0.1-0.5) | 0.1 (0.1-0.4) | 0.046 | |