Figure 1From: Recommendations for the management of tyrosinaemia type 1Tyrosine degradation pathway: HT1 is caused by a defect in the fumarylacetoacetase. Succinylacetone is a potent inhibitor of 5-aminolaevulinate dehydratase. Nitisinone inhibits 4-hydydroxyphenylpyruvate dioxygenase reducing flux through the pathway.Back to article page