Table 4 T lymphocyte profile of Olmsted syndrome case and age-matched healthy controls

T cells

CD3⁺

25.0

21.7 (10.7)

20.2 (8.48-41.6)

CD4 ⁺ subsets

CD4⁺ T cells

CD4⁺CD8^-

18.2

11.0 (6.03)

7.79 (3.82-19.9)

 →Treg

Foxp3⁺

1.91

3.67 (2.52)

2.97 (1.54-9.37)

 →Th1

IFNγ⁺

1.22

3.18 (1.57)

3.36 (0.96-5.28)

 →Th2

IL-4⁺

2.14

5.03 (2.45)

5.12 (1.90-11.0)

 →Th17

IL-17⁺

0.08

0.05 (0.04)

0.03 (0–0.1)

 →IL-2⁺

IL-2⁺

1.69

2.25 (1.06)

2.67 (0.95-4.11)

 →Tfh

CD45RA^-CXCR5⁺

0.59

0.14 (0.11)

0.11 (0.026-0.41)

 →Naïve

CD45RA⁺CCR7⁺

61.3

44.1 (9.73)

43.6 (31.0-58.4)

 →RTE

CD45RA⁺CCR7⁺CD31⁺

46.3

35.6 (8.77)

35.7 (22.8-49.7)

 →TCM

CD45RA^-CCR7⁺

14.6

12.2 (4.24)

11.6 (6.36-18.7)

 →TEM

CD45RA^-CCR7^-

15.6

32.5 (7.54)

35.2 (21.0-43.7)

 →TEMRA

CD45RA⁺CCR7^-

8.50

11.9 (5.55)

7.78 (6.52-21.2)

CD8 ⁺ subsets

CD8⁺ T cells

CD4^-CD8⁺

7.75

9.51 (4.12)

8.64 (4.45-17.5)

 →IFNγ⁺

IFNγ⁺

8.1

23.3 (9.09)

19.9 (12.7-40.0)

 →IL-2⁺

IL-2⁺

1.48

3.46 (1.74)

2.82 (1.78-7.17)

 →Naïve

CD45RA⁺CCR7⁺

60.9

41.2 (13.9)

37.4 (26.3-62.2)

 →RTE

CD45RA⁺CCR7⁺CD31⁺

59.0

38.2 (14.0)

32.3 (24.0-60.0)

 →TCM

CD45RA^-CCR7⁺

3.08

3.11 (1.52)

2.91 (1.08-6.00)

 →TEM

CD45RA^-CCR7^-

16.0

24.1 (7.63)

22.0 (14.8-41.3)

 →TEMRA

CD45RA⁺CCR7^-

20.1

31.6 (12.5)

31.2 (15.3-49.9)