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Table 3 Frequency of major leukocyte subsets from patient with mutation in TRPV3 and age-matched healthy controls

From: Olmsted syndrome: exploration of the immunological phenotype

Subset

Defining surface markers

Patient (%)

Healthy volunteers (%)

 
   

Mean (SD)

Median (min-max)

T cells

CD3+

25.0

21.7 (10.7)

20.2 (8.48-41.6)

B cells

CD19+

25.7

28.9 (11.5)

26.5 (16.9-55.1)

γδ T cells

γδ TCR+

0.25

0.23 (0.21)

0.15 (0.04-0.72)

iNKT cells

CD3+Vα24Jα18+

0.49

0.52 (0.25)

0.55 (0.09-0.89)

NKT cells

CD3+CD56+

2.49

10.2 (4.91)

9.35 (4.15-16.8)

NK cells

CD3-CD19-CD14-CD11c-CD56+

22.0

21.2 (10.1)

18.2 (9.17-40.8

Dendritic cells

CD3-CD19-CD14-CD56-

6.67

6.66 (2.76)

6.21 (2.96-11.4)

 →mDC

CD11c+HLA-DR+

35.5

41.4 (6.17)

42.2 (31.8-55.4)

 →pDC

CD11c-CD123+

21.3

16.8 (10.9)

19.9 (3.88-39.25)

  1. T cells are shown as percentage total leukocytes; B cells and γδ T cells are shown as percentage total lymphocytes; iNKT and NKT cells as percentage T cells; NK cells and dendritic cells are shown as percentage total leukocytes while mDC and pDC are shown as percentage dendritic cells.