Immunological profile of an Olmsted syndrome patient. Relative frequencies of peripheral blood leukocyte populations at 18 years of age, unless otherwise indicated. A) Major blood leukocyte subsets. B) Fluctuating peripheral blood eosinophil numbers over time, grey zone indicates normal range. C) Major CD4 T lymphocyte subsets. D) Helper T cell lineages. E) CD8 T lymphocyte subsets. F) B cell subsets. The described Olmsted Syndrome case is indicated by a filled circle and healthy age-matched controls are indicated as empty circles. The mean and standard deviation (error bars) shown exclude the values for the patient. TCM, central memory T cell; TEM, effector memory T cell; TEMRA, CD45RA-expressing effector memory T cell; Tfh, follicular T cell; Th1, type 1 helper T cell; Th2, type 2 helper T cell; Th17, IL-17-expressing helper T cell; RTE, recent thymic emigrant.