Table 9 Recommendations for follow-up
Test | Frequency | Grade |
|---|---|---|
SS-LCH And No Disease Activity | ||
History (especially of thirst, polyuria, cough, dyspnea, bone pain, skin changes, neurological symptoms) | • Every clinic visit | D2 |
Clinical assessment, blood count and blood chemistry (as described in baseline diagnostics), ultrasound | • End of therapy | D2 |
• every 6 month (for the next 2 years) | ||
• then once a year (for at least 3 years) | ||
Chest XR | • annually (for at least 3 years) | D2 |
After MS-LCH And With No Disease Activity | ||
History (especially of thirst, polyuria, cough, dyspnea, bone pain, skin changes, neurological symptoms) | • Every clinic visit | D2 |
Clinical assessment, blood count and blood chemistry (as described in baseline diagnostics), ultrasound | • End of therapy | D2 |
• every 3 month (for the next 2 years) | ||
• every 6 month (for the next 3 years) | ||
• then once a year (for at least 5 years) | ||
Chest XR | • annually (for at least 3 years) | D2 |
TSH, freeT4 | • Once a year (until end of routinely follow up) | D2 |
Patients With Active Disease | ||
Diagnostic procedures are depending on the site of organ involvement | Frequency is depending on rates and velocity of recurrences | D2 |
Patients With pLCH | ||
History (in case of non-pulmonary symptoms: look for MS LCH, see Table 4) | • Every clinic visit | D2 |
Diagnostic procedures are depending on symptoms und course of PLCH (baseline: Chest X-ray, lung function (+DCLO) | • End of therapy | D2 |
• every 6 month (for the next 2 years) | ||
• then once a year (for at least 5 years) | ||