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Table 6 Possible indications for the use of radiotherapy in adults

From: Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net

Recommendation Grade
Isolated “Unresectable” lesion: C2
if a resection would significantly compromise anatomic function, e.g. odontoid peg, CNS  
Recurrent or progressive lesion: C2
In multifocal or multisystem disease only in case of minor response to standard systemic therapy  
Adjuvant treatment following marginal or incomplete resection: especially in single system bone disease with soft tissue involvement C2