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Table 1 Grade of recommendation

From: Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net

Level of evidence Level of agreement between experts
A meta-analyses, high quality systematic reviews, or randomized controlled trials 2 general agreement between all experts
B systematic reviews of case control or cohort studies 1 discussed recommendation, but no formal objections between experts
C non-analytic studies: for example, case reports, case series, small retrospective studies 0 divergence of opinion
D expert opinion