Figure 3

Plasma arginine levels. Levels are shown in samples from patients in the French Barth syndrome cohort (15 samples) and in samples from an entire hospital patient population (12,828 samples). The plot shows that 95% of the samples from Barth Sd patients fall below the lower 25-percentile of randomly selected patients. Y-axis: concentration in micromoles/litre. From left to right, arginine levels in the hospital population (“all”) and in Barth syndrome patients (“Barth”). The box plots show the median values (horizontal bars), the 50th percentile around the median (box), and the full range of the 95th percentile distribution (dotted vertical lines). Circles indicate the values from individual samples from Barth syndrome patients. p-values: Wilcoxon rank sum test.