Results of blister counts show a significant reduction during P1. Patients received diacerein (grey graphs) to apply underneath both armpits during the open phase P1. During P2, one armpit was assigned to placebo (black graph) in a double-blinded, randomized manner. (A) During P1, there a significant reduction of blister numbers (given in%) from time span t1 to time span t2 and from t2 to t3 (t1:100%, t2:mean left: 22%/CI6-38; mean right: 34%/CI20-48). On both sides, t2 to t8 show a significant reduction of blisters compared to t1 (upper black line, * indicating a p-value ≤ 0.05). Blister numbers remained low until the end of the study period. The mean of blister numbers is given with 95% confidence intervals, whereby t1 is normalized to 100%. (B) During P2, there is a significant difference between placebo and diacerein at t7 (* indicates a p-value ≤ 0.05).