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Table 1 Demographic, clinical and laboratory data of all patients with glomerular disease and sarcoidosis

From: Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study

Characteristics

Overall population

MN

IgAN

MCNS

FSGS

Lupus nephritis

Number of patients

26

11(42%)

6 (23%)

3 (12%)

4 (15%)

2 (8%)

Sex (women/men)

8/18

3/8

2/4

0/3

2/2

1/1

Mean age at sarcoidosis diagnosis (yrs) (range)

37 (19–56)

39 (19–52)

34 (22–37)

36 (29–54)

40 (28–56)

36 (35–37)

Mean age at GD diagnosis (yrs) (range)

39 (0.6-59)

40 (27–57)

38 (22–53)

29 (0.5-59)

47 (38–57)

39 (36–44)

Number of patients with both conditions occurring simultaneously (%)

9 (35%)

3

3

1

2

0

Number of patients with GD before sarcoidosis (%)

6 (23%)

5

0

1

0

0

Number of patients with GD after sarcoidosis (%)

11 (42%)

3

3

1

2

2

Mean number of organs affected by sarcoidosis (range)

2.6 (1–6)

2.3 (1–3)

3.2 (1–6)

2.7 (2–3)

2.3 (1–4)

3.5 (3–4)

Steroid therapy for sarcoidosis (n)

16 (61%)

5

4

2

3

2

Sarcoidosis controlled by steroid therapy

8

2

3

2

1

0

Steroid-dependent or -resistant sarcoidosis

8

3

1

0

2

2

Mean creatinine level (mg/dL) (range)

1.40 (0.68-3.42)

1.30 (0.68-2.99)

1.63 (0.68-2.41)

1.14 (1.02-1.27)

1.75 (1.05-3.42)

0.94 (0.84-1.04)

Mean GFR (ml/min/1.73 m2) (range)

70.7 (16–133)

79.2 (23–133)

60.9 (26–97)

77.1 (62–92)

51.2 (16–73)

86 (61–111)

Mean proteinuria level (g/d) (range)

5.7 (0.45-20)

7.4 (0.86-20)

5 (1–12)

3.3 (3–3.6)

4.5 (1.7-6.6)

0.7 (0.45-1)

Serum albumin (g/L)

25,9 (9.7-43)

24,3 (9.7-43)

31 (17–39)

22.3 (15–29)

23.5 (11.3-38)

38 (38–38)

Number of patients with NS

15

7

2

3

3

0

GTIN associated with GD (number)

6

2

2

1

1

0

Mean follow-up (months)

101

124

48

157

80

72

Remission of GD at the end of the follow-up

      

CR

9

4

2

1

1

1

PR

7

3

2

1

1

0

Mean GFR at the end of the follow-up (ml/min/1.73 m2) *

67.8

68.7

76.4

68.1

48.3

66.5

End-stage renal disease during follow-up

6

2

1

1

1

1

Death during the follow-up

3

1

1

0

1

0

  1. MN: Membranous Nephropathy, IgAN: IgA nephropathy, MCNS: minimal change nephrotic syndrome, FSGS: focal and segmental glomerulosclerosis, GD: glomerular disease, GFR: glomerular filtration rate, NS: nephrotic syndrome, GTIN: granulomatous tubulointerstitial nephritis, CR: complete remission, PR: partial remission.
  2. * after exclusion of patients with end-stage renal disease.