From: Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study
Characteristics | Overall population | MN | IgAN | MCNS | FSGS | Lupus nephritis |
---|---|---|---|---|---|---|
Number of patients | 26 | 11(42%) | 6 (23%) | 3 (12%) | 4 (15%) | 2 (8%) |
Sex (women/men) | 8/18 | 3/8 | 2/4 | 0/3 | 2/2 | 1/1 |
Mean age at sarcoidosis diagnosis (yrs) (range) | 37 (19–56) | 39 (19–52) | 34 (22–37) | 36 (29–54) | 40 (28–56) | 36 (35–37) |
Mean age at GD diagnosis (yrs) (range) | 39 (0.6-59) | 40 (27–57) | 38 (22–53) | 29 (0.5-59) | 47 (38–57) | 39 (36–44) |
Number of patients with both conditions occurring simultaneously (%) | 9 (35%) | 3 | 3 | 1 | 2 | 0 |
Number of patients with GD before sarcoidosis (%) | 6 (23%) | 5 | 0 | 1 | 0 | 0 |
Number of patients with GD after sarcoidosis (%) | 11 (42%) | 3 | 3 | 1 | 2 | 2 |
Mean number of organs affected by sarcoidosis (range) | 2.6 (1–6) | 2.3 (1–3) | 3.2 (1–6) | 2.7 (2–3) | 2.3 (1–4) | 3.5 (3–4) |
Steroid therapy for sarcoidosis (n) | 16 (61%) | 5 | 4 | 2 | 3 | 2 |
Sarcoidosis controlled by steroid therapy | 8 | 2 | 3 | 2 | 1 | 0 |
Steroid-dependent or -resistant sarcoidosis | 8 | 3 | 1 | 0 | 2 | 2 |
Mean creatinine level (mg/dL) (range) | 1.40 (0.68-3.42) | 1.30 (0.68-2.99) | 1.63 (0.68-2.41) | 1.14 (1.02-1.27) | 1.75 (1.05-3.42) | 0.94 (0.84-1.04) |
Mean GFR (ml/min/1.73 m2) (range) | 70.7 (16–133) | 79.2 (23–133) | 60.9 (26–97) | 77.1 (62–92) | 51.2 (16–73) | 86 (61–111) |
Mean proteinuria level (g/d) (range) | 5.7 (0.45-20) | 7.4 (0.86-20) | 5 (1–12) | 3.3 (3–3.6) | 4.5 (1.7-6.6) | 0.7 (0.45-1) |
Serum albumin (g/L) | 25,9 (9.7-43) | 24,3 (9.7-43) | 31 (17–39) | 22.3 (15–29) | 23.5 (11.3-38) | 38 (38–38) |
Number of patients with NS | 15 | 7 | 2 | 3 | 3 | 0 |
GTIN associated with GD (number) | 6 | 2 | 2 | 1 | 1 | 0 |
Mean follow-up (months) | 101 | 124 | 48 | 157 | 80 | 72 |
Remission of GD at the end of the follow-up | Â | Â | Â | Â | Â | Â |
CR | 9 | 4 | 2 | 1 | 1 | 1 |
PR | 7 | 3 | 2 | 1 | 1 | 0 |
Mean GFR at the end of the follow-up (ml/min/1.73Â m2) * | 67.8 | 68.7 | 76.4 | 68.1 | 48.3 | 66.5 |
End-stage renal disease during follow-up | 6 | 2 | 1 | 1 | 1 | 1 |
Death during the follow-up | 3 | 1 | 1 | 0 | 1 | 0 |