Subject | Age | Gender | DM onset | DI onset | Optic atrophy onset | Hearing loss | Diagnosed with WFS | FH WFS | FH DM* | FH hearing loss* | Other problems |
---|---|---|---|---|---|---|---|---|---|---|---|
WU.WOLF-01 | 13.1 | M | 3.5 | 9 | 5 | 9 | N/A | N | Father | N | GERD, constipation, headaches, restless legs, hypothyroidism, hypogonadism |
WU.WOLF-02 | 10.9 | F | 6 | 7.5 | 9 | N | 9.5 | N | Mgaunt | Pgf | None |
WU.WOLF-03 | 17.9 | M | 5.0 | 6 | 6 | 6 | 6 | N | Mgf | mgm | GERD; restless legs; occasional myoclonus |
WU.WOLF-04 | 23.8 | F | 2.3 | 12 | 5 | 5 | 12 | N | Father, pgm, paunts | Father | GERD; OCD spectrum behaviors; constipation, loss of taste sensation |
WU.WOLF-05 | 13.8 | F | 3.8 | N | 12 | 1.7 | 13 | N | Mgf, mggm, mgaunt | mcousin | FTT at 1 year, feeding tube at age 2 1/2; Near-drowning age 6 ½; celiac sprue |
WU.WOLF-07 | 7.3 | M | 2.7 | 7 | N | 7 | 3 | Y† | Mgf, paunt, puncle, mggf, mguncle | Pgf, 3 pguncles | anxiety |
WU.WOLF-09 | 14.3 | M | 10.8 | 14 | 11 | N | N/A | Y‡ | Distant cousin, pggf | Maunt, muncle, pguncle, mggf | Asthma, migraines, obstructive sleep apnea constipation, |
WU.WOLF-10 | 11.7 | F | 7.0 | 11 | 9 | N | 8 | Y‡ | Distant cousin, pggf | Maunt, muncle, pguncle, mggf | GERD, headaches, night terrors, constipation |
WU.WOLF-11 | 8.3 | M | 7.5 | 10 | 6 | 8 | 7 | Y‡ | Distant cousin, pggf | Maunt, muncle, pguncle, mggf | headaches, constipation, loss of normal taste—“things taste funny” |
WU.WOLF-12 | 22.9 | M | 7.0 | 17 | 7 | 7 | 17 | N | Father (after kidney cancer), pgf, puncle, pggf, mgf, pguncle | N | GERD, myoclonus, neurogenic bladder, chronic renal failure, hypogonadism, loss of taste sensation |
WU.WOLF-13 | 5.9 | F | 4.8 | 7.5 | 5.2 | 6 | 5.4 | N | first cousin | N | Constipation |
WU.WOLF-14 | 13.6 | F | 6.3 | 11.3 | 7.9 | 10.1 | 8.8 | N | Mgf, pggm, mggf | N | None |
WU.WOLF-15 | 10.8 | F | 2.8 | N | 7 | 9 | 7 | N | N | brother | Constipation |
WU.WOLF-16 | 25.8 | F | 13.1 | 14.6 | 13.6 | 25.8 | 14.9 | N | pgf | pgm | None |
WU.WOLF-17 | 17.2 | F | 5 | N | 15.3 | 16.3 | 16.6 | N | Mother, maunt, mgm, mgf, mggf, mgaunt, mguncle, mcousin | mgaunt | None |
WU.WOLF-18 | 11.9 | M | 5.1 | 10.33 | 10.1 | 11.9 | 10.6 | N | Mgf | Father | None |
WU.WOLF-19 | 11.9 | F | N | N | 5 | Prior to 5 | 11 | No info | No info | No info | International adoption age 5, maternal half sibling is healthy. |
Constipation | |||||||||||
WU.WOLF-22 | 15.8 | F | 14 | N | 13 | N | 14.6 | N | Mggf, pgm, pgf | N | None |
MEAN | 14.2 | 6.3 | 10.6 | 8.7 | 9.0 | 10.3 | |||||
STD | 5.7 | 3.5 | 3.3 | 3.3 | 6.0 | 4.2 |