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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Intellectual disability associated with a homozygous missense mutation in THOC6

Figure 3

siRNA knockdown of THOC6 leads to increased apoptosis. HeLa cells transfected with THOC6-specific siRNA or no-targeting control siRNA were TUNEL stained. DAPI staining indicates the position of the nuclei. Knocking down of THOC6 resulted in an increased proportion of cells undergoing apoptosis with positive TUNEL staining (A), compared with the control siRNA transfected cells (B).

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