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Table 2 Clinical complications in 51 symptomatic PA patients based on medical records

From: Propionic acidemia: clinical course and outcome in 55 pediatric and adolescent patients

Affected organ/organ system Frequency in the study cohort of 55 PA patients
Bone marrow
  Pancytopenia 11%
  Neutropenia 29%
  Thrombocytopenia 35%
  Anemia 82%
Central and peripheral nervous system
  Psychomotor retardation 55%
  Delayed development of the speech 55%
  Muscular hypotonia 51%
  Metabolic stroke 9%
  Ataxia 9%
  Impaired hearing ability 13%
  Visual impairment 7%
Heart
  Long-QT syndrome 22%
  Cardiomyopathy 9%
Pancreas
  Pancreatitis 4%
Skeletal system
  Osteoporosis 2%