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Table 5 Multivariate Cox proportional hazard model evaluating predictors for disease progression and the necessity of repeated WLL

From: Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis

Variable

Hazard ratio*

CI 95%

p value

Disease progression

    

KL-6, U/mL (cont.)

0.999

0.998

1.000

0.090

KL-6 ≥1526, U/mL (binary)

3.844

0.460

288.120

0.046

  Gender (female=1) (binary)

18.030

2.378

136.696

0.051

Necessity of repeated WLL

    

KL-6, U/mL (cont.)

1.000

1.000

1.001

0.196

  PaO2, mmHg (cont.)

0.897

0.579

0.969

0.028

KL-6 ≥2157, U/mL (binary)

9.408

0.794

111.511

0.008

  PaO2, mmHg (cont.)

0.97

0.93

1.00

0.038

  LDH, IU/L (cont)

46.449

1.661

1299,262

0.024

  1. Definition of abbreviation: CI; confidence interval.
  2. * Calculated by stepwise conditional LR method. All significant predicting factors in the univariate analysis were included in the multivariate model. Only the factors that influence the model (adjusting factors) are reported in the Table.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172