Differences between sporadic and MEN related primary hyperparathyroidism; clinical expression, preoperative workup, operative strategy and follow-up

Table 3 Outcome of Surgery for Primary Hyperparathyroidism in Sporadic, MEN1 and MEN2A

Characteristics	Sporadic pHPT, n= 467	MEN1-pHPT, n= 52	MEN2A-pHPT, n= 16
Persistent disease, n
After first procedure	31 (7%)	11 (21%)	3 (19%)
After second procedure	6 (1%)	4 (8%)	1 (6%)
Recurrent disease, n
After first procedure	3 (<1%)	28 (54%)	2 (13%)
After second procedure	-	12 (24%)	1 (6%)
Complications, n
Recurrent laryngeal nerve injury	3 (<1%)	1 (2%)	1 (6%)
Hypocalcemia	1 (<1%)	10 (19%)	2 (13%)

Abbreviations: pHPT, primary hyperparathyroidism; MEN1, multiple endocrine neoplasia type 1; MEN2A, multiple endocrine neoplasia type 2A.