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Table 2 Surgery for Primary Hyperparathyroidism in Sporadic, MEN1 and MEN2A

From: Differences between sporadic and MEN related primary hyperparathyroidism; clinical expression, preoperative workup, operative strategy and follow-up

Characteristics Sporadic pHPT, n= 467 MEN1-pHPT, n= 52 MEN2A-pHPT, n= 16
Initial operation, n    
 Minimally invasive parathyroidectomy 328 (70%) 5 (10%) 6 (38%)
 Minimally invasive parathyroidectomy converted to conventional neck exploration 39 (8%) 3 (6%) 0
 Conventional neck exploration 100 (21%) 44 (84%) 10 (62%)
Subtotal parathyroidectomy, n - 38 (73%) -
Total parathyroidectomy, n - 6 (12%) -
Number of operations, n    
 One procedure 435 (93%) 26 (50%) 13 (81%)
 Two procedures 31 (7%) 17 (33%) 1 (6%)
 Three or more procedures 1 (<1%) 9 (17%) 2 (13%)
Mean number of operations 1.07 1.85 1.29
Cumulative operative findings, n    
 No adenoma found 6 (1%) - 1 (6%)
 1 enlarged gland 426 (91%) 17 (33%) 13 (81%)
  Solitary (adenoma, hyperplasia) 422 (90%) 17 (33%) 13 (81%)
  Carcinoma 4 (1%) - -
 > 1 enlarged glands 35 (7%) 35 (56%) 2 (13%)
  2 enlarged glands 26 (6%) 12 (23%) 2 (13%)
  3 enlarged glands 8 (2%) 17 (33%) -
  > 3 enlarged glands or hyperplasia 1 (<1%) 6 (12%) -
  1. Abbreviations: pHPT, primary hyperparathyroidism; MEN1, multiple endocrine neoplasia type 1; MEN2A, multiple endocrine neoplasia type 2A. Subtotal parathyroidectomy; (less than) SPTX. Total parathyroidectomy; TPTX.