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Table 2 Surgery for Primary Hyperparathyroidism in Sporadic, MEN1 and MEN2A

From: Differences between sporadic and MEN related primary hyperparathyroidism; clinical expression, preoperative workup, operative strategy and follow-up

Characteristics

Sporadic pHPT, n= 467

MEN1-pHPT, n= 52

MEN2A-pHPT, n= 16

Initial operation, n

   

 Minimally invasive parathyroidectomy

328 (70%)

5 (10%)

6 (38%)

 Minimally invasive parathyroidectomy converted to conventional neck exploration

39 (8%)

3 (6%)

0

 Conventional neck exploration

100 (21%)

44 (84%)

10 (62%)

Subtotal parathyroidectomy, n

-

38 (73%)

-

Total parathyroidectomy, n

-

6 (12%)

-

Number of operations, n

   

 One procedure

435 (93%)

26 (50%)

13 (81%)

 Two procedures

31 (7%)

17 (33%)

1 (6%)

 Three or more procedures

1 (<1%)

9 (17%)

2 (13%)

Mean number of operations

1.07

1.85

1.29

Cumulative operative findings, n

   

 No adenoma found

6 (1%)

-

1 (6%)

 1 enlarged gland

426 (91%)

17 (33%)

13 (81%)

  Solitary (adenoma, hyperplasia)

422 (90%)

17 (33%)

13 (81%)

  Carcinoma

4 (1%)

-

-

 > 1 enlarged glands

35 (7%)

35 (56%)

2 (13%)

  2 enlarged glands

26 (6%)

12 (23%)

2 (13%)

  3 enlarged glands

8 (2%)

17 (33%)

-

  > 3 enlarged glands or hyperplasia

1 (<1%)

6 (12%)

-

  1. Abbreviations: pHPT, primary hyperparathyroidism; MEN1, multiple endocrine neoplasia type 1; MEN2A, multiple endocrine neoplasia type 2A. Subtotal parathyroidectomy; (less than) SPTX. Total parathyroidectomy; TPTX.