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Table 2 Identification of reactive antigens in MMD

From: Immune response profiling identifies autoantibodies specific to Moyamoya patients

Protein name

Gene symbol

CI* P- value

Fold increase in MMD

Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha (CAMK2A)

CAMK2A

5.41E-06

18.2

B-cell antigen receptor complex-associated protein alpha-chain

CD79A

5.41E-06

2.5

EGF-like repeats and discoidin I-like domains 3 (EDIL3)

EDIL3

5.41E-06

3.5

Ectonucleoside triphosphate diphosphohydrolase 1

ENTPD1

5.41E-06

2.5

Proteinase 3

PRTN3

5.41E-06

2.1

Calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1

CAMK1D

5.95E-05

5.1

Ephrin-A3 (EFNA3)

EFNA3

5.95E-05

2.6

CD7 molecule (CD7)

CD7

3.57E-04

2.1

Na+/K + transporting ATPase interacting 4 (NKAIN4)

NKAIN4

3.57E-04

85.2

CDC-like kinase 4 (CLK4)

CLK4

5.47E-04

3.8

Interferon, alpha-inducible protein 6 (IFI6)

IFI6

5.47E-04

2.6

Casein kinase 1, delta (CSNK1D), transcript variant 1

CSNK1D

1.55E-03

5.5

Deiodinase, iodothyronine, type III (DIO3)

DIO3

2.74E-03

5.2

Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A)

FCGR3A

2.74E-03

2.2

RNA Polymerase

RNA POL

2.74E-03

3.7

Uncharacterized protein C20orf96

C20orf96

5.42E-03

4.5

cDNA clone MGC:31944 IMAGE:4878869, complete cds

CD247

5.42E-03

3.0

CD3d molecule, delta (CD3-TCR complex) (CD3D), transcript variant 1

CD3D

5.42E-03

2.8

Endoglin (Osler-Rendu-Weber syndrome 1) (ENG)

ENG

5.42E-03

2.4

Solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2)

SLC2A2

5.42E-03

3.7

Serine/threonine kinase 25 (STE20 homolog, yeast) (STK25)

STK25

5.42E-03

2.2

Transmembrane protein 32 (TMEM32)

TMEM32

5.42E-03

10.9

Chromosome 19 open reading frame 39 (C19orf39)

C19orf39

5.42E-03

4.1

Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D), transcript variant 3

CAMK2D

5.42E-03

3.8

G protein pathway suppressor 1

GPS1

5.42E-03

4.6

Raptor

KIAA1303

5.42E-03

3.0

LPS-responsive vesicle trafficking, beach and anchor containing (LRBA)

LRBA

5.42E-03

3.5

Melanocortin 2 receptor accessory protein (MRAP), transcript variant 1

MRAP

5.42E-03

3.2

NIMA (never in mitosis gene a)-related kinase 3 (NEK3), transcript variant 1

NEK3

5.42E-03

4.3

Receptor (chemosensory) transporter protein 2 (RTP2)

RTP2

5.42E-03

3.4

  1. The following is a subset of the most differentially expressed autoAbs increased by 2 fold or more in MMD compared to healthy controls (p ≤ 0.05).
  2. MMD = moyamoya disease.
  3. * CI p-value = Chebyshev’s Inequality p-value.