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Table 2 Identification of reactive antigens in MMD

From: Immune response profiling identifies autoantibodies specific to Moyamoya patients

Protein name Gene symbol CI* P- value Fold increase in MMD
Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha (CAMK2A) CAMK2A 5.41E-06 18.2
B-cell antigen receptor complex-associated protein alpha-chain CD79A 5.41E-06 2.5
EGF-like repeats and discoidin I-like domains 3 (EDIL3) EDIL3 5.41E-06 3.5
Ectonucleoside triphosphate diphosphohydrolase 1 ENTPD1 5.41E-06 2.5
Proteinase 3 PRTN3 5.41E-06 2.1
Calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1 CAMK1D 5.95E-05 5.1
Ephrin-A3 (EFNA3) EFNA3 5.95E-05 2.6
CD7 molecule (CD7) CD7 3.57E-04 2.1
Na+/K + transporting ATPase interacting 4 (NKAIN4) NKAIN4 3.57E-04 85.2
CDC-like kinase 4 (CLK4) CLK4 5.47E-04 3.8
Interferon, alpha-inducible protein 6 (IFI6) IFI6 5.47E-04 2.6
Casein kinase 1, delta (CSNK1D), transcript variant 1 CSNK1D 1.55E-03 5.5
Deiodinase, iodothyronine, type III (DIO3) DIO3 2.74E-03 5.2
Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A) FCGR3A 2.74E-03 2.2
RNA Polymerase RNA POL 2.74E-03 3.7
Uncharacterized protein C20orf96 C20orf96 5.42E-03 4.5
cDNA clone MGC:31944 IMAGE:4878869, complete cds CD247 5.42E-03 3.0
CD3d molecule, delta (CD3-TCR complex) (CD3D), transcript variant 1 CD3D 5.42E-03 2.8
Endoglin (Osler-Rendu-Weber syndrome 1) (ENG) ENG 5.42E-03 2.4
Solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) SLC2A2 5.42E-03 3.7
Serine/threonine kinase 25 (STE20 homolog, yeast) (STK25) STK25 5.42E-03 2.2
Transmembrane protein 32 (TMEM32) TMEM32 5.42E-03 10.9
Chromosome 19 open reading frame 39 (C19orf39) C19orf39 5.42E-03 4.1
Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D), transcript variant 3 CAMK2D 5.42E-03 3.8
G protein pathway suppressor 1 GPS1 5.42E-03 4.6
Raptor KIAA1303 5.42E-03 3.0
LPS-responsive vesicle trafficking, beach and anchor containing (LRBA) LRBA 5.42E-03 3.5
Melanocortin 2 receptor accessory protein (MRAP), transcript variant 1 MRAP 5.42E-03 3.2
NIMA (never in mitosis gene a)-related kinase 3 (NEK3), transcript variant 1 NEK3 5.42E-03 4.3
Receptor (chemosensory) transporter protein 2 (RTP2) RTP2 5.42E-03 3.4
  1. The following is a subset of the most differentially expressed autoAbs increased by 2 fold or more in MMD compared to healthy controls (p ≤ 0.05).
  2. MMD = moyamoya disease.
  3. * CI p-value = Chebyshev’s Inequality p-value.