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Figure 5 | Orphanet Journal of Rare Diseases

Figure 5

From: Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures

Figure 5

Effects of 2-MCA, MMA and PA on glucose and lactate levels. Glucose (A) and lactate (B) were measured in the medium of cultures from DIV 8 and DIV 14. Cultures were exposed to 1 mM 2-MCA, MMA or PA (A and B; left panel, DIV 8 and 14) or lower concentrations of 2-MCA (A and B; right panel, DIV 14). Mean ± SEM of 4 to 7 replicate cultures assessed by Student’s t-test; **p<0.01, *** p<0.001.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172