Manifestation of 10 characteristic neurological NP-C signs relative to diagnosis. Sequence of occurrence of 10 selected neurological symptoms with diagnostic importance (acc. to Wijburg et al., 2012, ), normalized to the relative age at diagnosis (y=0). Each dot represents one patient. Medians are indicated by grey bars. Symptoms are aligned in order of appearance (bottom to top). VSGP, vertical supranuclear gaze palsy.