Spectrum of disease presentation in studied neurological NP-C patient cohort (n=38). Horizontal bars show disease duration (in years) in individual patients (represented by NPC-cdb no.; see Figure 1) from the onset of neurological symptoms until the age at data assessment. Dark blue, timespan from first reported neurological sign until diagnosis NP-C. Light blue, timespan from diagnosis until data assessment. In four patients NP-C was diagnosed prior to the onset of neurological signs (narrow bars). Deceased patients are highlighted by crosses. Patients are aligned according to age at diagnosis.