Figure 1

Characterization of a BIN-67 xenograft model of SCCOHT. A) Kaplan-Meier curve showing the survival of mice following intraperitoneal injection of BIN-67 cells. The cells form tumours with a median survival of 82 days. B) Quantification of tumour localization in the xenografts showed that the incidence of tumours is highest on the pancreas, omentum and spleen and is associated with the ovary in 56% of the mice. C) The formation of tumours is associated with a significant increase in serum ionized calcium (iCa) in the mice at endpoint (n=11) compared with levels measured in samples taken before the xenograft (n=4; * p<0.05).