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Table 5 The burden of disease in Germany based on prevalence data from the literature

From: Cost of illness and economic burden of chronic lymphocytic leukemia

     Sickness fund perspective Societal perspective
      Year Study origin Prevalence Lower limit (2.5%) Burden (mean) Upper limit (97.5%) Direct costs Indirect costs Lower limit (2.5%) Burden (mean) Upper limit (97.5%)
This study 2007/2008 Germany 4.95 €187.6 m €201.1 m €223.6 m €189.7 m €132.0 m €302.3 m €321.7 m €341.3 m
Orphanet database2    2011 not stated/global 3.00 €113.8 m €122.0 m €135.6 m €115.0 m €80.1 m €183.4 m €195.1 m €207.0 m
Reis et al.1    2000 Germany 4.53     €262.0 m €52.0 m   €314.0 m  
Reis et al. (adj.)2 2007/2008 Germany 4.53 €171.8 m €184.3 m €204.9 m €173.7 m €121.0 m €277.0 m €294.7 m €312.7 m
SEER database2    2008 USA 3.47 €131.6 m €141.1 m €156.9 m €133.1 m €92.6 m €212.1 m €225.7 m €239.5 m
  1. 1) as reported by Reis et al. (2006); 2) calculated based cost data of this study.