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Table 2 Treatment for clinical symptoms of transthyretin familial polyneuropathy (TTR-FAP)

From: Guideline of transthyretin-related hereditary amyloidosis for clinicians

Symptom Treatment
Arrhythmias Pacemaker implantation, pharmacotherapy
Cardiac failure Diuretics, angiotensin converting enzyme inhibitors
Orthostatic hypotension Droxidopa, midodrine, amezinium metisulfate, fludrocortisone, plastic stocking, abdominal belt, elevating head
Gastrointestinal disorders (not severe) Polycarbophil calcium, metoclopramide
Severe diarrhea Loperamide
Neuropathic pain Pregabalin, gabapentin, amitriptyline, duloxetine
Carpal tunnel syndrome Surgery
Dry mouth Potassium dihydrogen phosphate, cevimeline
Hypoglycemia Glucose loading
Renal failure Hemodialysis
Urinary incontinence Distigmine
Anemia Erythropoietin, iron
Hypothyroidism Levothyroxine
Ocular amyloidosis Vitrectomy, trabeculectomy