Figure 4From: Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disabilityExpression levels of JARID2 (A) and ATXN1 (B) in leucocytes from our four patients with deletion of one or both of these genes (Patients 1-4 and Patients 1-3 and 5, respectively), compared with eight healthy controls. JARID2 and ATXN1 levels were measured using four and three primer pairs targeting the transcripts, respectively (JARID2-1, -2, -3 and -4, and ATXN1-1, -2 and -3). Primer sequences are given in Additional file 1: Table S1). JARID2 expression level was significantly reduced in the patients compared to the controls (p ≤ 0.01), while the ATXN1 expression level was not significantly altered (p ≤ 0.1). Ctrl, Control; Pt, Patient.Back to article page