Table 3 The main findings of genetically analyzed IP patients and CNS anomalies according to the presence of genetically confirmed IKBKG mutation for the period 2001-2012
From: Systematic review of central nervous system anomalies in incontinentia pigmenti
IP patients with and without genetical confirmation of the IKBKG mutation | Number of | Distribution of CNS anomaly types in numbers | Distribution of IP patients according to severity of anomalies in numbers | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Neurologically investigated IP patients with CNS anomalies | CNS anomaly types | CNS anomaly types per patient | Seizures | Mental retardation | Motor impairment | Microcephaly | CNS anomalies found in small number or unspecified | IP patients with mild CNS anomalies | IP patients with severe CNS anomalies | |
Total | 205 | 329 | 1.60 | 141 | 66 | 82 | 12 | 28 | 80 | 125 |
IP patients without genetical confirmation | 155 | 252 | 1.62 | 111 | 55 | 69 | 9 | 8 | 57 | 98 |
IP patients with genetical confirmation | 50 | 77 | 1.54 | 30 | 11 | 13 | 3 | 20 | 23 | 27 |