Skip to main content

Table 1 Pathway ontology associated with the CHI disease network

From: Can network biology unravel the aetiology of congenital hyperinsulinism?

Network module

Biological pathway

FDR

  Cellular Signalling

Tropomyosin Receptor Kinase Signalling

5.0 × 10-5

RAF/MAP Kinase Cascade

5.3 × 10-5

Neurotrophin Signalling

5.9 × 10-5

mTOR Signalling

6.3 × 10-5

Syndecan-1-mediated Signalling

4.0 × 10-4

TRAIL Signalling

3.0 × 10-4

  Nuclear Signalling

Regulation of SMAD2/3 Signalling

1.0 × 10-4

Oestrogen Receptor-α Signalling

1.1 × 10-4

Oestrogen Receptor-β Signalling

1.5 × 10-4

Retinoic Acid Receptor Signalling

1.4 × 10-4

 Growth Factor Signalling

BARD1 Signalling Events

1.3 × 10-4

p53 Signalling pathway

2.0 × 10-4

HDAC Class III Signalling

1.0 × 10-3

TGFβ Signalling

2.6 × 10-4

  Development

ErbB2/ErbB3 Signalling

6.6 × 10-3

Presenilin Signalling

9.0 × 10-3

GMCSF-Mediated Signalling

6.6 × 10-3

  Function

Integration of Energy Metabolism

1.0 × 10-3

  1. Five network modules associate with the CHI Disease Network (Figure 1) and each module has nodes which are represented in a number of canonical biological pathways (http://www.ncbi.nlm.nih.gov/biosystems/). Several of these have been highlighted for each module along with their False Discovery Rate (FDR) which represents the chance occurrence of nodes being co-located with pathways.
Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172