Figure 2
From: A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus
General hypothesis for the pathogenesis of SLE. Increased production of apoptotic blebs and/or reduced clearance of apoptotic blebs lead to the release of chromatin into the circulation. Presence of chromatin in circulation leads to the activation of antigen-presenting cells (APCs) and the formation of pathogenic immune complexes that incite glomerulonephritis. From Munoz et al. 2008 [20], copyright © 2011 by SAGE Publishing, reprinted by permission of SAGE.