Figure 3
From: A xenograft animal model of human arteriovenous malformations
The immunostaining for VEGFR-2. (IHC × 200). (A) A lot of AVM “nidus” ECs in the grafts were positive for VEGFR-2. Tortuous thick-walled arteries and veins were noted in the peripheral area (arrow). (B) The ECs in the pre-implanted human AVM “nidus” were positive for VEGFR-2. (C) The ECs of arteries and veins in pre-implanted human AVM specimens were positive for VEGFR-2. (D) Unaffected mouse skin and subcutaneous tissues were negative for VEGFR-2.