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Table 2 Kinetic parameters for tyrosylation of tRNA Tyr by wild-type and p.Gly191Asp YARS2 recombinant proteins

From: Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia

YARS2 Variant K m (μM) kcat(min-1) kcat/K m (Efficiency) Loss of Efficiencya(Fold change)
WT 1 34 34 1
p.Gly191Asp 1 0.9 0.9 38
  1. aLoss of efficiency is calculated relative to the wild-type YARS2.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172