Figure 1

Plotting of cumulative index of 183 NCL cases born in 1966–2010 as ascertained by CLNet. Patients are sorted by year of birth and plotted by number of new cases per year (dark dots) and cumulative number of cases. The curve shows relatively steady recruitment of new cases over time, with a slight deflection from the mid-1980s to the mid-1990’s (circled). The flat ends of the curve are possibly related to under-diagnosis during the late-1960s to early-1970s, and the presence of still undiagnosed cases today (right end of the curve).