Skip to main content

Table 2 Symptoms before diagnosis in MPS III Subtypes

From: Natural history of Sanfilippo syndrome in Spain

Symptoms before diagnosis MPS Subtype (N°) N° casos Median
A B C Age
(Range)
Coarse facial features 24 9 9 42 78% 3 years
( 1 – 4 y)
Recurrent diarrhea 17 4 6 27 50% 2 years
(1 – 4.5 y)
Umbilical hernia 7 4 1 12 22% 1 months
(0 – 8 months)
Inguinal hernia 4 0 0 4 7% 1,6 year
( 0–3 y)
Recurrent otitis 15 5 5 25 46% 1 year
(0–3.5 y)
Hearing loss 12 2 6 11 30% 2.2 year
(1.5 – 6 y)
Adenoidectomy 14 2 7 23 43% 3 year
(2 – 6 y)
Tonsillectomy 8 3 4 15 28% 3.8 year
(2 – 9 y)
Speech delayed 27 11 8 46 85% 3 year
(2.5 – 7 y)
Hyperactivity 21 6 8 35 65% 3 year
(1.5 – 10 y)
Sleep disorders 14 5 5 24 44% 1 year
( 2 months -6 y)