Figure 2

Hierarchy of GO terms significantly associated to HSCR in the different populations analyzed with the Nsp and Sty chips, separately (See Table2). Red color means that the GO term, originally significant in the Spanish population [17] was also significant in all the four Consortium populations in at least one of the chips (FDR-adjusted p-values < 0.05) using the PBA approach described in Methods. In Orange color are represented those initially red color GO term in which there seems to be a potential bias due to the size of the genes composing the GO. In green color there is a GO term, significant in the Spanish population and significant in only one population of the consortium (USA). The blue color correspond GO terms that were not initially significant in the Spanish population but were consistently significant through the populations analyzed here.