Figure 4
From: The effects of Eculizumab on the pathology of malignant atrophic papulosis
A and B: C5b-9 in submucosal vessels of intestinal resection specimens pre- and post-eculizumab, respectively. Immunohistochemical assessment reveals marked deposition of C5b-9 in vessels of the submucosa in the pre-eculizumab specimen (A, diaminobenzidene, 400x) while the intestinal resection specimen procured 21 months after commencing therapy (B, diaminobenzidene 400x) is devoid of vascular staining apart from nonspecific staining within the elastic tissue of blood vessels.