Molecular modeling of MYO7A containing the p.W2160G mutation. (A) Structural motif of myosin 7A. Tryptophan 2160 on the C-terminal 4.1 protein-ezrin-radixin-moesin (FERM) domain is indicated by an arrow. Motor, myosin motor domain; IQ, Isoleucine-glutamine calmodulin-binding motif; CC, coiled-coil domain; MyTH4, myosin tail homology 4 domain; SH3, Src homology 3 domain. (B) Ribbon model of the C-terminal FERM domain consisting of three subdomains (F1, F2, F3) and an MyTH4 domain. (C, D) Magnified ribbon model of the F3 subdomain superimposed with predicted surface hydrophobicity in the wild type (C) and the p.W2160G mutant (D).