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Table 6 Recommendations for monitoring iron overload

From: Organizing national responses for rare blood disorders: the Italian experience with sickle cell disease in childhood

Recommendations Evidence
Serum ferritin level could increase during VOC; assessment at steady state is recommended. C
Serial measurements of serum ferritin and iron intake are recommended before starting iron chelation therapy. C
LIC (liver iron concentration), measured by magnetic resonance T2* or R2*, SQUID (superconducting quantum interference device), or MID (magnetic iron detector), all techniques available in Italy, should be assessed before starting iron chelation therapy. C
Cardiac iron assessment, measured by magnetic resonance T2*, is recommended before starting iron chelation therapy. C