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Table 2 Alternative drugs for antibiotic prophylaxis

From: Organizing national responses for rare blood disorders: the Italian experience with sickle cell disease in childhood

Proposing group Age Recommendation for antibiotic prophylaxis
   Antibiotic Dose Frequency
Working Party of the British Committee for <5 y Amoxicillin 10 mg/kg/d Once a day
Standards in Haematology Clinical 5–14 y Amoxicillin 125 mg/d Once a day
Haematology Task Force [25, 26] >14 y Amoxicillin 250–500 mg/d Once a day
The Hospital for Sick Children, Toronto [2729] 2–6 months Trimethoprim/sulfamethoxazole TMP 5 mg SMX 25 mg/kg Once a day
6 months–5 y Amoxicillin 20 mg/kg/d Twice a day
>5 y Amoxicillin 250 mg/day Twice a day
Australasian Society for Infectious Diseases [30] 2 months–2 y Amoxicillin 20 mg/kg/d Once a day
   (max 250 mg/d) Once a day
  Adults Amoxicillin 250 mg/d