Organizing national responses for rare blood disorders: the Italian experience with sickle cell disease in childhood

Table 2 Alternative drugs for antibiotic prophylaxis

Proposing group	Age	Recommendation for antibiotic prophylaxis
		Antibiotic	Dose	Frequency
Working Party of the British Committee for	<5 y	Amoxicillin	10 mg/kg/d	Once a day
Standards in Haematology Clinical	5–14 y	Amoxicillin	125 mg/d	Once a day
Haematology Task Force [25, 26]	>14 y	Amoxicillin	250–500 mg/d	Once a day
The Hospital for Sick Children, Toronto [27–29]	2–6 months	Trimethoprim/sulfamethoxazole	TMP 5 mg SMX 25 mg/kg	Once a day
	6 months–5 y	Amoxicillin	20 mg/kg/d	Twice a day
	>5 y	Amoxicillin	250 mg/day	Twice a day
Australasian Society for Infectious Diseases [30]	2 months–2 y	Amoxicillin	20 mg/kg/d	Once a day
Australasian Society for Infectious Diseases [30]			(max 250 mg/d)	Once a day
	Adults	Amoxicillin	250 mg/d

ISSN: 1750-1172