Table 4 Cost and cost-effectiveness of universal GA-I newborn screening at differing prevalence rates and low versus high incremental screening cost
Incremental screening cost 0.03 Euro/neonate | Incremental screening cost 0.3 Euro/neonate | |||
|---|---|---|---|---|
Prevalence | Mean incremental cost per 100000 screened neonates (95% CI) | ICER | Mean incremental cost per 100000 screened neonates (95% CI) | ICER (95% CI) |
1 in 35,000 | −103,445 (−160,339 – -52,919) | <0 | −76,545 (−133,439 – -26,019) | <0 |
1 in 100,000 | −34,191 (−54,104 – -16,507) | <0 | −7,291 (−27,204 – 10,393) | −1,750 (−6,417 - 2,657) |
1 in 200,000 | −15,545 (−25,502 – -6,703) | <0 | 11,355 (1,398 – 20,197) | 5,703 (651 – 10,728) |
1 in 350,000 | −7,555 (− 13,244 – - 2,502) | <0 | 19,345 (13,656 – 24,398) | 16,882 (10,800 – 23,491) |