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Figure 1 | Orphanet Journal of Rare Diseases

Figure 1

From: Niemann-Pick disease type C symptomatology: an expert-based clinical description

Figure 1

Clinical assessment of vertical supranuclear gaze palsy. During the neurological evaluation of eye movements, assessing eye pursuit movements alone (left) is insufficient: voluntary saccades must be tested (right). The examiner should require the subject to visually fixate on two separate objects, e.g. the examiner’s finger and a hatpin, which are displaced first horizontally and then vertically (up and down), but always within the subject’s visual field. The subject is then asked to look at each object alternately.

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