Figure 3
From: The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy
Exposure to intense light induces a severe retinal degeneration in Mo-AdamTS18-injected medaka fish. Representative frontal eye sections, immunostained with an anti-Rhodopsin antibody (green), from P5 control (A) and Mo-AdamTS18–injected (B) medaka fish after 5 days of constant light exposure. Sections are counterstained with DAPI (blue). We observed a significant reduction in both the thickness of the photoreceptor outer segment (OS) and in the intensity of rhodopsin staining in Mo-AdamTS18–injected medaka fish as compared with control animals following constant and intense light exposure. A’ and B’ are higher magnifications of the areas marked by the white dashed boxes in A and B, respectively. Other abbreviations: ONL, Outer Nuclear Layer; INL, Inner Nuclear Layer. Scale bars, red lines: 20 μm.