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Table 2 Tests for epistatic effect of p.L444P or p.N370S and markers at GBA2 locus on severity of Gaucher disease

From: Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease

 

p.L444P

p.N370S

GBA2 SNP

POShg18

MA

P single

P nom

P corr

P nom

P corr

rs10814274

35724942

T

0.811

0.0224

0.3195

0.4648

1.0000

rs34312177

35730649

T

0.769

0.0672

0.6933

0.4809

1.0000

rs3833700

35738696

T

0.847

0.0045

0.0735

0.9861

1.0000

rs1570246

35738843

A

0.811

0.0223

0.3195

0.4648

1.0000

rs3750434

35738985

T

0.739

0.0235

0.3328

0.4673

1.0000

rs1570247

35739264

T

1.000

0.0253

0.3528

0.8580

1.0000

rs2236288

35739837

G

0.518

0.1145

0.8734

0.9957

1.0000

rs1570249

35741250

T

0.811

0.0224

0.3195

0.4648

1.0000

rs2145923

35742243

C

0.480

0.4546

1.0000

0.8296

1.0000

rs1322045

35742487

C

0.880

0.0048

0.0787

0.9844

1.0000

rs1570250

35742683

T

0.847

0.0045

0.0735

0.9861

1.0000

rs34478611

35743925

T

0.622

0.0428

0.5245

0.9975

1.0000

rs4878628

35744491

T

0.998

0.0016

0.0272

0.9886

1.0000

rs10814275

35748564

G

0.408

0.6472

1.0000

0.6777

1.0000

rs1570248

35756549

G

0.847

0.0045

0.0735

0.9861

1.0000

rs10972579

35766001

T

0.118

0.0548

0.6163

0.7097

1.0000

rs10972581

35769559

T

0.900

0.0995

0.8316

0.2835

0.9965

  1. MA Minor Allele, P single p-value for logistic regression single-marker analysis, P nom and P corr p-Values for genotypic interaction without taking marginal effects into account (nominal and corrected for number of markers at GBA2 locus). P-values are in bold in case they reach the level of nominal significance (P < 0.05).
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172