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Table 2 Tests for epistatic effect of p.L444P or p.N370S and markers at GBA2 locus on severity of Gaucher disease

From: Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease

  p.L444P p.N370S
GBA2 SNP POShg18 MA P single P nom P corr P nom P corr
rs10814274 35724942 T 0.811 0.0224 0.3195 0.4648 1.0000
rs34312177 35730649 T 0.769 0.0672 0.6933 0.4809 1.0000
rs3833700 35738696 T 0.847 0.0045 0.0735 0.9861 1.0000
rs1570246 35738843 A 0.811 0.0223 0.3195 0.4648 1.0000
rs3750434 35738985 T 0.739 0.0235 0.3328 0.4673 1.0000
rs1570247 35739264 T 1.000 0.0253 0.3528 0.8580 1.0000
rs2236288 35739837 G 0.518 0.1145 0.8734 0.9957 1.0000
rs1570249 35741250 T 0.811 0.0224 0.3195 0.4648 1.0000
rs2145923 35742243 C 0.480 0.4546 1.0000 0.8296 1.0000
rs1322045 35742487 C 0.880 0.0048 0.0787 0.9844 1.0000
rs1570250 35742683 T 0.847 0.0045 0.0735 0.9861 1.0000
rs34478611 35743925 T 0.622 0.0428 0.5245 0.9975 1.0000
rs4878628 35744491 T 0.998 0.0016 0.0272 0.9886 1.0000
rs10814275 35748564 G 0.408 0.6472 1.0000 0.6777 1.0000
rs1570248 35756549 G 0.847 0.0045 0.0735 0.9861 1.0000
rs10972579 35766001 T 0.118 0.0548 0.6163 0.7097 1.0000
rs10972581 35769559 T 0.900 0.0995 0.8316 0.2835 0.9965
  1. MA Minor Allele, P single p-value for logistic regression single-marker analysis, P nom and P corr p-Values for genotypic interaction without taking marginal effects into account (nominal and corrected for number of markers at GBA2 locus). P-values are in bold in case they reach the level of nominal significance (P < 0.05).