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Figure 1 | Orphanet Journal of Rare Diseases

Figure 1

From: Functional and genetic characterization of the non-lysosomal glucosylceramidase 2 as a modifier for Gaucher disease

Figure 1

Quantitative mass spectrometric analysis of HexCer (sum of GlcCer and GalCer). (A) Total HexCer amount in liver, spleen, and brain of 6 -month-old GBA2-deficient (KO) and wild-type (WT) mice. (B) Amount of the HexCer species carrying the typical neuronal ceramide anchor with a stearic acyl residue. *: P < 0.05, n = 4 animals per group. (C) TLC of a representative brain lipid sample in which GlcCer and GalCer are separated. Note the increased GlcCer in the KO. The double band reflects heterogeneity of its ceramide anchor composition.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172