Long-term neurological outcome of a cohort of 80 patients with classical organic acidurias

Table 1 Plasma amino acid levels in relation to disease and age

1A. Joint effect of disease and age on plasma amino acid levels
	Disease	Age	Age and disease interaction
Plasma alanine	0.0010**	0.0069**	0.027*
Plasma glutamine	0.0000***	0.0012**	0.030*
Plasma glycine	0.0000***	0.0000***	0.0001***
1B. Effect of age on plasma amino acid levels for each disease
	IVA	MMA	PA
Plasma alanine	0.051	0.068	0.0041**
Plasma glutamine	0.17	0.39	0.0005**
Plasma glycine	0.22	0.011*	0.0000***

A: Joint effect of disease status and age on plasma amino acid levels (two-way ANOVA, p-values). B: Effect of age on plasma amino acid levels for each disease (one-way ANOVA, p-values). To enhance readability, p-values are rounded following the first non-zero digit or at total four digits. Significance cutoffs for p-values: * < 0.05; ** < 0.01; *** < 0.001.

ISSN: 1750-1172