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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Identification and characterization of regulatory elements in the promoter of ACVR1, the gene mutated in Fibrodysplasia Ossificans Progressiva

Figure 3

Functional characterization of the 2. 9 kb promoter region of human ACVR1 gene. A) Schematic representation of the deletion constructs derived from the ACVR1 2.9 kb promoter region. These reporter constructs were transiently transfected in U2OS (B), HeLa (C), C2C12 (D) and ATDC5 cells (E), together with the pRL-TK-Renilla plasmid as a control for transfection efficiency. The corresponding observed activities are shown as relative to the activity of the Pr-2.9 ACVR1 promoter construct (100%). The data represent the mean ± SD (error bars) of five independent experiments conducted in triplicate, with p < 0.05*, p < 0.01**, or p < 0.001*** comparing the activity of each deletion construct with the 2.9 kb promoter.

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