Skip to main content

Table 4 Forty-eight hour in vitro cortisol responses to hormonal stimuli in AIMAH cells

From: ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitroresponses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase

  Dose n Partial response n (%) Full response n (%) Correlation with in vivotest Correlation with t=2 h
ACTH1-24 10 ng/ml 7 0 6 (86%) −0.39 0.20
AngII 100 nM 4 0 4 (100%) 1.00**# n.a.
AVP 10 nM 3 0 2 (67%) 0.50; n.a.# n.a.
AVP 100 nM 7 1 (14%) 6 (86%) −0.18; -0.086# −0.50
Desmopressin 10 nM 5 0 0 −0.67 1.00**
Metoclopramide 1 μM 4 0 2 (50%) 0.60 1.00**
Norepinephrine 1 μM 4 0 0 −0.50# −0.50#
hCG 100 IU/ml 4 0 0 −0.60 −0.50
TSH 10 nM 2 0 1 (50%) n.a. n.a.
Glucagon 1 μM 4 0 0 −0.20 n.a.
GIP 100 nM 2 0 0 −1.00 n.a.
  1. **p<0.01, standard mixed meal, # upright posture test, AVP im, n.a. not applicable.